# SkewDB: an open database of GC and other microbial skews

DevFeed: [SkewDB: an open database of GC and other microbial skews](<https://devfeed.tech/articles/skewdb-an-open-database-of-gc-and-other-microbial-skews-36540.md>)

Original publisher: [Read original article](<https://berthub.eu/articles/posts/skewdb-an-open-database-of-gc-and-other-microbial-skews/>)

Published: 2021-08-30T12:19:18Z

Content type: article

Language: en

Sources: [Bert Hubert's writings](<https://devfeed.tech/sources/bert-hubert-s-writings.md>)

Topics: [Database](<https://devfeed.tech/topics/database.md>), [Replication](<https://devfeed.tech/topics/replication.md>), [Open Source](<https://devfeed.tech/topics/open-source.md>), [Software](<https://devfeed.tech/topics/software.md>)

Tags: [biology](<https://devfeed.tech/tags/biology.md>), [database](<https://devfeed.tech/tags/database.md>), [dna](<https://devfeed.tech/tags/dna.md>), [open-source](<https://devfeed.tech/tags/open-source.md>), [replication](<https://devfeed.tech/tags/replication.md>), [software](<https://devfeed.tech/tags/software.md>)

## AI overview

This article introduces SkewDB, an open downloadable database containing GC skew and other nucleotide skews for 28,000 bacterial chromosomes from the NCBI genomes service. It explains how GC skew relates to DNA replication and describes the database's potential for exploring and testing hypotheses.

## Source excerpt

Hello and welcome to this introduction of the SkewDB. This open (downloadable) database contains details of GC skew, plus a dozen other skews, for all 28,000 bacterial chromosomes available through the NCBI genomes service. The database is created using the open source Antonie DNA software. There is also an online viewer that includes graphs. GC skew is the phenomenon where almost all circular chromosomes tend to have near equal amounts of G and C nucleotides, per strand, but where the leading replication strand contains an excess of G, and the lagging replication strand has an excess of C nucleotides.