# Proteins

Published articles for Proteins.

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## PottsMPNN uses machine learning to improve computational protein design

DevFeed: [PottsMPNN uses machine learning to improve computational protein design](<https://devfeed.tech/articles/looking-beyond-natural-sequences-37963.md>)

Original publisher: [Read original article](<https://news.mit.edu/2026/looking-beyond-natural-sequences-0827>)

Author: Lillian Eden | Department of Biology

Published: 2026-08-27T19:20:00Z

Content type: news

Language: en

Sources: [MIT AI News](<https://devfeed.tech/sources/mit-ai-news.md>)

Topics: [Machine learning](<https://devfeed.tech/topics/machine-learning.md>), [Artificial Intelligence](<https://devfeed.tech/topics/ai.md>)

Tags: [ai](<https://devfeed.tech/tags/ai.md>), [ai-in-biology](<https://devfeed.tech/tags/ai-in-biology.md>), [amino-acids](<https://devfeed.tech/tags/amino-acids.md>), [amy-keating](<https://devfeed.tech/tags/amy-keating.md>), [artificial-intelligence](<https://devfeed.tech/tags/artificial-intelligence.md>), [biological-engineering](<https://devfeed.tech/tags/biological-engineering.md>), [biology](<https://devfeed.tech/tags/biology.md>), [computational-protein-design](<https://devfeed.tech/tags/computational-protein-design.md>), [computer-science-and-technology](<https://devfeed.tech/tags/computer-science-and-technology.md>), [foster-birnbaum](<https://devfeed.tech/tags/foster-birnbaum.md>), [machine-learning](<https://devfeed.tech/tags/machine-learning.md>), [mit-department-of-biology](<https://devfeed.tech/tags/mit-department-of-biology.md>), [native-sequence-recovery](<https://devfeed.tech/tags/native-sequence-recovery.md>), [novel-protein-design](<https://devfeed.tech/tags/novel-protein-design.md>), [pottsmpnn](<https://devfeed.tech/tags/pottsmpnn.md>), [proteins](<https://devfeed.tech/tags/proteins.md>), [research](<https://devfeed.tech/tags/research.md>), [school-of-engineering](<https://devfeed.tech/tags/school-of-engineering.md>), [school-of-science](<https://devfeed.tech/tags/school-of-science.md>)

### AI overview

Researchers developed PottsMPNN, a machine-learning framework for computational protein design that incorporates physical principles governing protein structure and stability. The framework evaluates generated sequences by their likelihood of folding into desired structures and by its ability to predict mutation effects, rather than by how closely they match naturally occurring sequences.

### Source excerpt

A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.

## The Genetic Code and Proteins of the Other Covid-19 Vaccines

DevFeed: [The Genetic Code and Proteins of the Other Covid-19 Vaccines](<https://devfeed.tech/articles/the-genetic-code-and-proteins-of-the-other-covid-19-vaccines-36413.md>)

Original publisher: [Read original article](<https://berthub.eu/articles/posts/genetic-code-of-covid-19-vaccines/>)

Published: 2021-01-12T12:47:18Z

Content type: article

Language: en

Sources: [Bert Hubert's writings](<https://devfeed.tech/sources/bert-hubert-s-writings.md>)

Topics: [Reverse Engineering](<https://devfeed.tech/topics/reverse-engineering.md>), [Code](<https://devfeed.tech/topics/code.md>)

Tags: [biology](<https://devfeed.tech/tags/biology.md>), [covid](<https://devfeed.tech/tags/covid.md>), [covid-19](<https://devfeed.tech/tags/covid-19.md>), [dna](<https://devfeed.tech/tags/dna.md>), [proteins](<https://devfeed.tech/tags/proteins.md>), [research](<https://devfeed.tech/tags/research.md>)

### AI overview

The article compares genetic differences among major SARS-CoV-2 vaccines, focusing on mRNA and viral-vector vaccines and how they express modified or unmodified Spike protein. It lists products including BioNTech/Pfizer, Moderna, CureVac, Oxford/AstraZeneca, Janssen, and Sputnik V.

### Source excerpt

Translations: 中文, 日本語 As a followup to Reverse Engineering the source code of the BioNTech/Pfizer SARS-CoV-2 Vaccine, here is a look at the genetic code behind some of the other vaccines. I recommend at least skimming the earlier post before delving into this one, unless you are already fluent in modified mRNA bases and protein expression mechanics. To get an extremely full background on all vaccine work, I kindly refer you to excellent posts from Derek Lowe and Hilda Bastian.

## DNA: The Code of Life

DevFeed: [DNA: The Code of Life](<https://devfeed.tech/articles/dna-the-code-of-life-36365.md>)

Original publisher: [Read original article](<https://berthub.eu/articles/posts/dna-the-code-of-life/>)

Published: 2017-08-12T18:01:03Z

Content type: article

Language: en

Sources: [Bert Hubert's writings](<https://devfeed.tech/sources/bert-hubert-s-writings.md>)

Topics: [Code](<https://devfeed.tech/topics/code.md>), [Computing](<https://devfeed.tech/topics/computing.md>), [Programming](<https://devfeed.tech/topics/programming.md>)

Tags: [3d](<https://devfeed.tech/tags/3d.md>), [biology](<https://devfeed.tech/tags/biology.md>), [code](<https://devfeed.tech/tags/code.md>), [digital](<https://devfeed.tech/tags/digital.md>), [dna](<https://devfeed.tech/tags/dna.md>), [programming](<https://devfeed.tech/tags/programming.md>), [proteins](<https://devfeed.tech/tags/proteins.md>)

### AI overview

A brief introduction to presentations arguing that DNA in living cells can be usefully described and studied with computer terminology. It covers DNA's digital representation, genes, redundancy, the relationship between DNA, RNA and proteins, ribosomes, codons, and biological function calls.

### Source excerpt

DNA: The Code of Life At the most magical SHA2017 gathering I gave two presentations, "DNA: The Code of Life" and the followup, "DNA: More greatest hits" (slides). The first presentation was recorded by the wonderful CCC C3VOC streaming crew, the second one by my friend Bart Smit (who is also wonderful). Without making this post too long, I want to thank everyone who helped me do this presentation -- a lot of people contributed time, advice, recording abilities, great questions and enthusiasm.